KOODAKPRESS

Data-driven tool defines risk stages for children with chronic kidney disease

Experts in pediatric kidney disease have published a new staging system to help doctors better predict the length of time until a child with chronic kidney disease (CKD) will need to undergo a kidney transplant or start receiving dialysis. Although this type of prognostic guide exists for adults, this is the first such tool specific to children.

According to koodakpress، We designed a clinically useful, data-driven tool for doctors and nurses to advise parents and plan treatment, based on when a child’s kidney disease is likely to progress to the need for transplant or dialysis,” said study leader Susan L. Furth, MD, Chief of Nephrology at Children’s Hospital of Philadelphia (CHOP).

Furth and colleagues published their study today in the American Journal of Kidney Diseases.

Healthcare providers currently rely mainly on their own clinical experience to estimate when their patients’ condition will progress to end-stage renal disease. “Having the proper amount of lead time is important,” said Furth. “One key factor is evaluating living donors who intend to donate one of their kidneys for transplant.” The donor’s workup needs to be current, within a year of the transplant, stressed Furth. After a year, another full workup is necessary.

The researchers drew on two, large multicenter study consortia of children with chronic kidney disease. The Chronic Kidney Disease in Children (CKid) study gathered data on 891 patients from North American centers, while the ESCAPE (Effect of Strict Blood Pressure Control and ACE Inhibition) study was a European clinical trial with data from 378 pediatric patients.

The study team concluded that a combination of three factors provide the best predictors for estimating disease progression: glomerular filtration rate (which measures how efficiently the kidney filters waste products from the blood), proteinuria (the presence of protein in the urine), and whether the CKD is caused by a glomerular or nonglomerular etiology. In glomerular kidney disease, inflammation in the glomeruli, the kidney’s filtration units, impairs normal filtration. In nonglomerular disease, more common in children than adults, structural abnormalities or inherited conditions disrupt kidney function.

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